Department of Obstetrics and Gynecology, Shanghai General Hospital,
Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China
Received November 19, 2017; Accepted June 20, 2018
DOI: 10.3892/ol.2018.9023
Abstract
Hydrogen (H2) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic
applications. H2 can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or
saline to produce H2 water or H2‑rich saline. H2 selectively reduces oxidants of the detrimental reactive oxygen species
(ROS), including hydroxyl radicals (·OH) and peroxynitrite (ONOO ‑), which serve a causative role in promoting tumor cell proliferation, invasion, and metastasis, but do not disturb metabolic oxidation‑reduction reactions in cell
signaling. Compared with traditional antioxidants, H2 is a small molecule that can easily dissipate throughout the body
and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H2 may involve correction of the oxidative/anti‑oxidative imbalance and suppression of inflammatory mediators. Therefore the present review will discuss the anti‑inflammatory and anti‑tumorigenic action of H2 via ROS.
The full article is attached.
Hydrogen (H2) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic
applications. H2 can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or
saline to produce H2 water or H2‑rich saline. H2 selectively reduces oxidants of the detrimental reactive oxygen species
(ROS), including hydroxyl radicals (·OH) and peroxynitrite (ONOO ‑), which serve a causative role in promoting tumor cell proliferation, invasion, and metastasis, but do not disturb metabolic oxidation‑reduction reactions in cell
signaling. Compared with traditional antioxidants, H2 is a small molecule that can easily dissipate throughout the body
and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H2 may involve correction of the oxidative/anti‑oxidative imbalance and suppression of inflammatory mediators. Therefore the present review will discuss the anti‑inflammatory and anti‑tumorigenic action of H2 via ROS.
The full article is attached.